Matching infection in a single population.
Go to our modeling page
to learn more.
Modeling and Epidemiology
This year, our team worked on engineering an epidemic by simulating the spread of an infection in a biological model system. Our model has multiple levels, which we matched to experimental data one at a time. Click here to read more about our modeling experience.
E.coli infected with fluorescent phage.
This cell is lytic: the green spots are new phage particles being constructed prior to lysis.
Using a Biological Model System
λ phage and E. coli constitute our model system. λ phage has two infection pathways: lysis and lysogeny. A lytic cell will burst shortly after infection, while a lysogenic cell stays dormant. In order to find out which pathway had been chosen in our bacteria, we constructed a reporter plasmid.