http://2007.igem.org/wiki/index.php?title=Paris/Project_Description&feed=atom&action=historyParis/Project Description - Revision history2024-03-28T13:14:52ZRevision history for this page on the wikiMediaWiki 1.16.5http://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=36678&oldid=prevVieira at 12:42, 25 October 20072007-10-25T12:42:07Z<p></p>
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</table>Vieirahttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=33149&oldid=prevDavidpz: /* <center>The SMB: Synthetic Multicellular Bacterium</center> */2007-10-24T07:33:15Z<p><span class="autocomment"><center>The SMB: Synthetic Multicellular Bacterium</center></span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== <center>The SMB: Synthetic Multicellular Bacterium</center> == <br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== <center>The SMB: Synthetic Multicellular Bacterium</center> == <br></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green <del class="diffchange diffchange-inline">cell</del>), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green <ins class="diffchange diffchange-inline">cells</ins>), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td></tr>
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</table>Davidpzhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=33148&oldid=prevDavidpz: /* <center>The SMB: Synthetic Multicellular Bacterium</center> */2007-10-24T07:33:00Z<p><span class="autocomment"><center>The SMB: Synthetic Multicellular Bacterium</center></span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== <center>The SMB: Synthetic Multicellular Bacterium</center> == <br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== <center>The SMB: Synthetic Multicellular Bacterium</center> == <br></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line. It is able to differentiate into the second line: the soma, which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line <ins class="diffchange diffchange-inline">(red cells)</ins>. It is able to differentiate into the second line: the soma <ins class="diffchange diffchange-inline">(green cell)</ins>, which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td></tr>
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</table>Davidpzhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=32407&oldid=prevVieira at 22:28, 23 October 20072007-10-23T22:28:55Z<p></p>
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</table>Vieirahttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=29031&oldid=prevDavid.bikard at 14:57, 21 October 20072007-10-21T14:57:04Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line. It is able to differentiate into the second line: the soma, which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line. It is able to differentiate into the second line: the soma, which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.</div></td></tr>
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</table>David.bikardhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=29029&oldid=prevDavid.bikard at 14:56, 21 October 20072007-10-21T14:56:01Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><font size</del>=<del class="diffchange diffchange-inline">20</del>><del class="diffchange diffchange-inline">This page is under construction</del></<del class="diffchange diffchange-inline">font><br</del>><br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>=<ins class="diffchange diffchange-inline">= <center</ins>><ins class="diffchange diffchange-inline">The SMB: Synthetic Multicellular Bacterium</ins></<ins class="diffchange diffchange-inline">center</ins>> <ins class="diffchange diffchange-inline">== </ins><br></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The <ins class="diffchange diffchange-inline">aim of our project </ins>is to <ins class="diffchange diffchange-inline">engineer the first synthetic </ins>multicellular <ins class="diffchange diffchange-inline">bacterium, the SMB</ins>. This <ins class="diffchange diffchange-inline">new </ins>organism <ins class="diffchange diffchange-inline">is a new tool for the engineering </ins>of <ins class="diffchange diffchange-inline">complex biological systems. It consists in two interdependent cell lines</ins>. The first one<ins class="diffchange diffchange-inline">, dedicated to reproduction will </ins>be <ins class="diffchange diffchange-inline">called </ins>the germ line<ins class="diffchange diffchange-inline">. It is able to differentiate into </ins>the <ins class="diffchange diffchange-inline">second line: </ins>the soma<ins class="diffchange diffchange-inline">, which is sterile and dedicated to support the germ line</ins>. The germ line <ins class="diffchange diffchange-inline">is </ins>auxotroph for <ins class="diffchange diffchange-inline">DAP (diaminopimelate) </ins>which <ins class="diffchange diffchange-inline">is </ins>provided by the soma<ins class="diffchange diffchange-inline">. There is thus an interdependency relationship</ins>. The soma<ins class="diffchange diffchange-inline">, being sterile, doesn't exist without </ins>the germ line to <ins class="diffchange diffchange-inline">generate it</ins>, <ins class="diffchange diffchange-inline">and </ins>the germ line <ins class="diffchange diffchange-inline">needs the </ins>soma to <ins class="diffchange diffchange-inline">complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as </ins>the <ins class="diffchange diffchange-inline">almost complete construction </ins>of the <ins class="diffchange diffchange-inline">SMB</ins>.</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">Il faudrait mettre ici un abstract digne de ce nom... En attendant, je laisse ca...</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The <del class="diffchange diffchange-inline">idea </del>is to <del class="diffchange diffchange-inline">make a </del>multicellular <del class="diffchange diffchange-inline">organism out of bacteria</del>. This <del class="diffchange diffchange-inline">simple </del>organism <del class="diffchange diffchange-inline">will have two distinct types </del>of <del class="diffchange diffchange-inline">cells</del>. The first one <del class="diffchange diffchange-inline">would </del>be the germ line<del class="diffchange diffchange-inline">, </del>the <del class="diffchange diffchange-inline">other one </del>the soma. The germ line <del class="diffchange diffchange-inline">will be </del>auxotroph for <del class="diffchange diffchange-inline">a given nutriment, </del>which <del class="diffchange diffchange-inline">will be </del>provided by the soma. The soma <del class="diffchange diffchange-inline">will differentiate from </del>the germ line <del class="diffchange diffchange-inline">and will be unable </del>to <del class="diffchange diffchange-inline">divide. In this way</del>, <del class="diffchange diffchange-inline">there is a need for a part of </del>the germ line <del class="diffchange diffchange-inline">to differentiate into </del>soma <del class="diffchange diffchange-inline">in order </del>to <del class="diffchange diffchange-inline">feed </del>the <del class="diffchange diffchange-inline">rest </del>of the <del class="diffchange diffchange-inline">germ line Hence, the soma doesn't exist without a germ line to generate it</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
</table>David.bikardhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=26661&oldid=prevDavid.bikard at 14:20, 17 October 20072007-10-17T14:20:15Z<p></p>
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</table>David.bikardhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=26641&oldid=prevDavid.bikard at 14:00, 17 October 20072007-10-17T14:00:42Z<p></p>
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</table>David.bikardhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=26623&oldid=prevDavid.bikard at 13:14, 17 October 20072007-10-17T13:14:47Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><font size=20>This page is under construction</font><br><br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><font size=20>This page is under construction</font><br><br></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">Il faudrait mettre ici un abstract digne de ce nom... En attendant, je laisse ca...</ins></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The idea is to make a multicellular organism out of bacteria. This simple organism will have two distinct types of cells. The first one would be the germ line, the other one the soma. The germ line will be auxotroph for a given nutriment, which will be provided by the soma. The soma will differentiate from the germ line and will be unable to divide. In this way, there is a need for a part of the germ line to differentiate into soma in order to feed the rest of the germ line Hence, the soma doesn't exist without a germ line to generate it.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>The idea is to make a multicellular organism out of bacteria. This simple organism will have two distinct types of cells. The first one would be the germ line, the other one the soma. The germ line will be auxotroph for a given nutriment, which will be provided by the soma. The soma will differentiate from the germ line and will be unable to divide. In this way, there is a need for a part of the germ line to differentiate into soma in order to feed the rest of the germ line Hence, the soma doesn't exist without a germ line to generate it.</div></td></tr>
</table>David.bikardhttp://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=26622&oldid=prevDavid.bikard at 13:10, 17 October 20072007-10-17T13:10:06Z<p></p>
<a href="http://2007.igem.org/wiki/index.php?title=Paris/Project_Description&diff=26622&oldid=26616">Show changes</a>David.bikard