Samantha Liang

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Contents

BactoBlood

Someone should replace this block of text the next time they have downtime - Networks of interacting cells provide the basis for neural learning. We have developed the process of addressable conjugation for communication within a network of E. coli bacteria. Here, bacteria send messages to one another via conjugation of plasmid DNAs, but the message is only meaningful to cells with a matching address sequence. In this way, the Watson Crick base-pairing of addressing sequences replaces the spatial connectivity present in neural systems. To construct this system, we have adapted natural conjugation systems as the communication device. Information contained in the transferred plasmids is only accessable by "unlocking" the message using RNA based 'keys'. The resulting addressable conjugation process is being adapted to construct a network of NAND logic gates in bacterial cultures. Ultimately, this will allow us to develop networks of bacteria capable of trained learning.


Team members

Advisors
John Dueber
Christopher Anderson
Adam Arkin
Jay Keasling

Teaching Assistants
Farnaz Nowroozi
Amin Hajimorad
Rickey Bonds

Undergraduate Researchers
Arthur Yu
Austin Day
David Tulga
Kristin Doan
Samantha Liang
Vaibhavi Umesh
Kristin Fuller

High School Students
Coming soon!

Team Resources

Oligo List Spreadsheet
Our BioBrick Parts
All construction files
All sequencing files


Tools and Guides

Biobricks and Cloning Tutorials
Pairwise Alignment Online
Wiki Formatting Guide

Team Notebooks

John Dueber Notebook
Christopher Anderson Notebook
Farnaz Nowroozi Notebook
Amin Hajimorad Notebook
Rickey Bonds Notebook
Arthur Yu's 1337 Notebook
Austin Day Notebook
David Tulga Notebook
Kristin Doan Notebook
Samantha Liang Notebook
Vaibhavi Umesh Notebook
Kristin Fuller Notebook