Tokyo/Formulation/2.toggle model with hybrid promoter

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<br>Assuming the system where ''E. coli'' does not produce AHL by themselves, we have observed the system's reaction to ''ab extra'' AHL. The ODEs were obtained as
<br>Assuming the system where ''E. coli'' does not produce AHL by themselves, we have observed the system's reaction to ''ab extra'' AHL. The ODEs were obtained as
-
<br>[[Image:expression2-1.jpg|200px|]]
+
<br>[[Image:expression2-3.jpg|300px|]]
<br>where the factor surrounded in the orange box represents the activation of promoter B.
<br>where the factor surrounded in the orange box represents the activation of promoter B.
 +
<br>These equations were normalized as follows:
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<br>The ideal behavior shown in the figure below is:
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<br>[[Image:expression2-4.jpg|250px|]]
 +
 
 +
<br>Figure● represent the our thinking behavior of this system.
<br>- with low concentration of AHL, the B state becomes unstable. so that the cells at the B state move to the A state which is stable.
<br>- with low concentration of AHL, the B state becomes unstable. so that the cells at the B state move to the A state which is stable.
-
<br>- with hign concentration of AHL, both A and B states are stable.The cells at the A state keep the A state,that at the B state keep the B state. 
+
<br>- with hign concentration of AHL, both A and B states are stable.The cells at the A state keep the A state and that at the B state keep the B state. 
<br>[[Image:AHLresponse2-2.jpg|300px|]]
<br>[[Image:AHLresponse2-2.jpg|300px|]]
-
<br>実際に,式を解いて相平面を書いてみると図のようになる.
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<br>The phase plane and the bifurcation are shown in Fig●:
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<br>The phaseplane drawn by solving the equations is the following:
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-
 
+
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<br>[[Image:expression2-2.jpg|200px|]]
+
-
 
+
<br>[[Image:AHLresponse2-3.jpg|330px|]][[Image:AHLresponse2-4.jpg|300px|]][[Image:AHLresponse2-5.jpg|300px|]]
<br>[[Image:AHLresponse2-3.jpg|330px|]][[Image:AHLresponse2-4.jpg|300px|]][[Image:AHLresponse2-5.jpg|300px|]]
 +
<br>分岐図を載せる!!!!!!!

Revision as of 13:20, 23 October 2007


AHLresponse2-1.jpg


Assuming the system where E. coli does not produce AHL by themselves, we have observed the system's reaction to ab extra AHL. The ODEs were obtained as


Expression2-3.jpg


where the factor surrounded in the orange box represents the activation of promoter B.
These equations were normalized as follows:


Expression2-4.jpg


Figure● represent the our thinking behavior of this system.
- with low concentration of AHL, the B state becomes unstable. so that the cells at the B state move to the A state which is stable.
- with hign concentration of AHL, both A and B states are stable.The cells at the A state keep the A state and that at the B state keep the B state. 


AHLresponse2-2.jpg


The phase plane and the bifurcation are shown in Fig●:


AHLresponse2-3.jpgAHLresponse2-4.jpgAHLresponse2-5.jpg
分岐図を載せる!!!!!!!