University of Bologna Cesena Campus iGEM2007 Team/Project Description

From 2007.igem.org

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'''Genetic Schmitt Trigger - University of Bologna Cesena Campus 2007 Team.'''
'''Genetic Schmitt Trigger - University of Bologna Cesena Campus 2007 Team.'''
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The aim of this project is to build a Genetic Schmitt Trigger, a peculiar switch where the on/off transition is regulated by a couple of different thresholds to confer to the system an improved noise margin via an hysteretical property. The Schmitt Trigger is a well known electronic component, originally invented by Otto Schmitt who was involved (in research on electric impulse propagation in squid axons. We are charmed by the idea to bring back this concept into synthetic biology. Indeed, hysteresis is already present in many biological systems, such as the lac operon of E. coli (xx, xx): our goal is to build up a synthetic device out of it.  
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The aim of this project is to build a Genetic Schmitt Trigger, a peculiar switch where the on/off transition is regulated by a couple of different thresholds to confer to the system an improved noise margin via an hysteretical property. The Schmitt Trigger is a well known electronic component, originally invented by Otto Schmitt who was involved (in research on electric impulse propagation in squid axons. We are charmed by the idea to bring back this concept into synthetic biology. Indeed, hysteresis is already present in many biological systems, such as the lac operon of E. coli: our goal is to build up a synthetic device out of it.  
We plan to assemble BioBricks from iGEM 2007 plates to make new ones mimicking some of the functional units of the lac operon labelled with a fluorescent tag to implement a complete project of synthetic sugar biosensor.
We plan to assemble BioBricks from iGEM 2007 plates to make new ones mimicking some of the functional units of the lac operon labelled with a fluorescent tag to implement a complete project of synthetic sugar biosensor.

Revision as of 12:52, 1 August 2007

Genetic Schmitt Trigger - University of Bologna Cesena Campus 2007 Team. The aim of this project is to build a Genetic Schmitt Trigger, a peculiar switch where the on/off transition is regulated by a couple of different thresholds to confer to the system an improved noise margin via an hysteretical property. The Schmitt Trigger is a well known electronic component, originally invented by Otto Schmitt who was involved (in research on electric impulse propagation in squid axons. We are charmed by the idea to bring back this concept into synthetic biology. Indeed, hysteresis is already present in many biological systems, such as the lac operon of E. coli: our goal is to build up a synthetic device out of it. We plan to assemble BioBricks from iGEM 2007 plates to make new ones mimicking some of the functional units of the lac operon labelled with a fluorescent tag to implement a complete project of synthetic sugar biosensor.