Virginia/Projects/1
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New approaches to metabolic engineering made possible by the development of genomics, systems biology, and synthetic biology have enabled metabolic pathway design in microorganisms for the production of transportation fuels such as ethanol, butanol and hydrogen (Stephanopoulos 2007). The novel microbial metabolism developed by the 2007 Virginia Genetically Engineered Machine (VGEM) Team for the production of butanol from cellulose and light is illustrated below in Figure 1. There are four main systems that comprise the pathway; cellulose metabolism, light metabolism, butanol biosynthesis, and butanol tolerance have extended E. coli K-12’s natural central metabolic pathway. In this way, a valuable chemical product such as butanol biofuel can be biologically manufactured using inexpensive feedstock material. The cellulose and light metabolizing systems may one day serve as engines in future system designs to drive forward the biosynthesis of chemical products in microorganisms. | New approaches to metabolic engineering made possible by the development of genomics, systems biology, and synthetic biology have enabled metabolic pathway design in microorganisms for the production of transportation fuels such as ethanol, butanol and hydrogen (Stephanopoulos 2007). The novel microbial metabolism developed by the 2007 Virginia Genetically Engineered Machine (VGEM) Team for the production of butanol from cellulose and light is illustrated below in Figure 1. There are four main systems that comprise the pathway; cellulose metabolism, light metabolism, butanol biosynthesis, and butanol tolerance have extended E. coli K-12’s natural central metabolic pathway. In this way, a valuable chemical product such as butanol biofuel can be biologically manufactured using inexpensive feedstock material. The cellulose and light metabolizing systems may one day serve as engines in future system designs to drive forward the biosynthesis of chemical products in microorganisms. | ||
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Revision as of 01:26, 27 October 2007
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Harvesting Cellulose and Light to Power Butanol Biosynthesis
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Approach
New approaches to metabolic engineering made possible by the development of genomics, systems biology, and synthetic biology have enabled metabolic pathway design in microorganisms for the production of transportation fuels such as ethanol, butanol and hydrogen (Stephanopoulos 2007). The novel microbial metabolism developed by the 2007 Virginia Genetically Engineered Machine (VGEM) Team for the production of butanol from cellulose and light is illustrated below in Figure 1. There are four main systems that comprise the pathway; cellulose metabolism, light metabolism, butanol biosynthesis, and butanol tolerance have extended E. coli K-12’s natural central metabolic pathway. In this way, a valuable chemical product such as butanol biofuel can be biologically manufactured using inexpensive feedstock material. The cellulose and light metabolizing systems may one day serve as engines in future system designs to drive forward the biosynthesis of chemical products in microorganisms.
