ICAM-based Targeting and Signaling

== How it works ==
1. Infarced myocardium induces expression of ICAM.

2. Two LFA-1's on our programmed cells bind to the same ICAM dimer on a damaged cardiomyocyte. 

3. 50% of the time LFA-1 – Cub will be in close proximity of LFA-1 – NubG.

4. When this occurs, the Cub and NubG of split ubiquitin interact and reconstitute the ubiquitin.

5. Ubiquitin protease then cleaves the Cub portion of ubiquitin and releases the transcription factor LexA-VP16.

6. LexA-VP16 travels to the nucleus, binds to the lexA operator minimal promoter, and effectors such as N-cadherin, VEGF, are upregulated.

[[Image:Icam.jpg]]