Berkeley UC OxygenTransport Chaperones Cytochromes

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  <div align="center"><span class="style5"><a href="https://2007.igem.org/Berkeley_UC_Immunity"><span class="style30">Next</span><br />
  </a></span><a href="https://2007.igem.org/Berkeley_UC_Immunity"><img src="https://static.igem.org/mediawiki/2007/a/a0/F-Blue.gif" alt="" name="UCForwardButton" width="54" height="41" id="UCForwardButton" /></a></div>
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    <p class="style28"><span class="style34"><a href="https://2007.igem.org/Berkeley_UC_Introduction">Introduction</a></span><a href="https://2007.igem.org/Berkeley_UC_OxygenTransport" TITLE="Hemoglobin production and maintenance is essential for oxygen delivery."><br>
    <span class="style31"> Oxygen Transport </span></a> </p>
    <ul>
      <li class="style29"><span class="style29"><a TITLE="Human hemoglobin alpha is our choice of oxygen carrier." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Hemoglobin">Hemoglobin</a></span></li>
      <li><span class="style29"><a TITLE="Chaperones allow our hemoglobin to fold and function properly." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones">Chaperones </a></span>
        
        <ul>
          <li class="style29"><span class="style30"><a TITLE="Heme is the oxygen binding component of hemoglobin." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones_Heme">Heme</a></span></li>
          <li><span class="style30"><a TITLE="Alpha hemoglobin stabilizing protein (AHSP) helps hemoglobin fold properly." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones_AHSP">AHSP</a></span></li>
          <li><span class="style30"><a TITLE="Cytochrome b5 and b5 reductase help to keep the hemoglobin in its functional form." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones_Cytochromes"><font color="#FF0000">Cytochrome b5</a></span></li>
          <li><span class="style30"><a TITLE="Cytochrome b5 and b5 reductase help to keep the hemoglobin in its functional form." href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones_Cytochromes"><font color="#FF0000">Cytochrome b5 Reductase</a></span><a href="https://2007.igem.org/Berkeley_UC_OxygenTransport_Chaperones_AHSP"><br />
          </a> </li>
        </ul>
      </li>
    </ul>
    <a href="https://2007.igem.org/Berkeley_UC_Immunity" TITLE="Our bacterial chassis has been heavily modified to remove its sepsis-inducing toxicity, immunogenic factors, and ability to grow within the bloodstream, as well as promote its ability to last longer in the bloodstream by masking it from the immune system." class="style31">Immunity</a>    
    <ul class="style29">
      <li><a href="https://2007.igem.org/Berkeley_UC_Immunity_Chassis" TITLE="Our bacterial chassis has been modified to resist destruction by the immune system.">Chassis</a></li>
      <li><a TITLE="A deletion of the msbB gene allows our chassis to be less immunogenic." href="https://2007.igem.org/Berkeley_UC_Immunity_msbBDeletion">msbB Deletion</a></li>
    </ul>
    <p><a href="https://2007.igem.org/Berkeley_UC_GrowthControl" TITLE="Growth aided by antioxidants in vitro and inhibited in vivo by lack of free iron." class="style31">Growth Control</a></p>
    <ul class="style29"><li><a TITLE="Antioxidants help to prevent damage by superoxide radicals." href="https://2007.igem.org/Berkeley_UC_Antioxidants" class="style29">Antioxidants</a> 
      <ul>
        <li><span class="style30"><a TITLE="Antioxidants help to prevent damage by superoxide radicals." href="https://2007.igem.org/Berkeley_UC_Antioxidants">SodC</a></span></li>
        <li><span class="style30"><a TITLE="Antioxidants help to prevent damage by superoxide radicals." href="https://2007.igem.org/Berkeley_UC_Antioxidants">KatG</a></span></li>
        </ul>
    </li>
    
      <li><a href="https://2007.igem.org/Berkeley_UC_GrowthControl_tonBDeletion" TITLE="TonB is essential for high affinity iron uptake." class="style29">TonB Deletion</a><a href="https://2007.igem.org/Berkeley_UC_GrowthControl_tonBDeletion"><br>
      </a></li>
    </ul>
    <p><span class="style28"><span class="style31"><a href="https://2007.igem.org/Berkeley_UC_KillSwitch" TITLE="To prevent chance of infection or unwanted proliferation after hemoglobin production." class="style31">Genetic Self Destruct</a></span></span></p>
    <p class="style31"><a TITLE="The Controller is an integrated genetic circuit comprised of two plasmids." href="https://2007.igem.org/Berkeley_UC_SystemController">SystemController</a></p>
    <span class="style31"><a TITLE="To enable preservation of our bacteria for long time periods, we are including the ability to produce the compounds hydroxyectoine and trehalose that will enable our bacteria to survive freeze-drying intact.  This will dramatically increase shelf-life and decrease transport costs." href="https://2007.igem.org/Berkeley_UC_Storage" class="style31">Storage</a></span></div>
  <p class="style17">&nbsp;</p>
  <p class="style17">&nbsp;</p>
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