Bangalore
From 2007.igem.org
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| - | Mukund: Chief Mentor, Consultant and The Godfather | + | *Mukund: Chief Mentor, Consultant and The Godfather |
| - | Sugat Right-hand Man and Manager of Operations | + | *Sugat Right-hand Man and Manager of Operations |
| - | Nilesh The Man for all Seasons | + | *Nilesh The Man for all Seasons |
| - | Vivek Chief Troubleshooter, often his role is confused with one of a Troublemaker | + | *Vivek Chief Troubleshooter, often his role is confused with one of a Troublemaker |
| - | Krishna: The Sharpshooter | + | *Krishna: The Sharpshooter |
| - | Senthil: The Wikiman, also fondly referred to as the "Bio Info God" | + | *Senthil: The Wikiman, also fondly referred to as the "Bio Info God" |
| - | Varun: The Voice of Reason and Anti-Reason | + | *Varun: The Voice of Reason and Anti-Reason |
| - | K12Z1: The Workhorse | + | *K12Z1: The Workhorse |
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== The Mission == | == The Mission == | ||
Revision as of 07:29, 29 May 2007
The Company
- Mukund: Chief Mentor, Consultant and The Godfather
- Sugat Right-hand Man and Manager of Operations
- Nilesh The Man for all Seasons
- Vivek Chief Troubleshooter, often his role is confused with one of a Troublemaker
- Krishna: The Sharpshooter
- Senthil: The Wikiman, also fondly referred to as the "Bio Info God"
- Varun: The Voice of Reason and Anti-Reason
- K12Z1: The Workhorse
The Mission
To investigate multistability and hysteresis in combinatorially constructed synthetic Vibrio quorum sensing circuits
The Target - Vibrio Quorum Sensing System
Quorum sensing is a phenomenon by which bacteria sense a critical cell density before turning on the expression of certain genes. It involves the gradual build-up of a chemical termed the 'autoinducer' in the cell. The autoinducer freely diffuses across the cell membrane and hence, its concentration is population density dependent. When the concentration crosses a threshold, the bacteria switch to a different physiological state such as bioluminescence, virulent gene expression, and bio-film formation.
In Vibrio fischeri, when the population density (and hence the concentration of autoinducer) crosses a certain threshold, the expression of a set of genes that is required for bioluminescence is turned on. The production of the autoinducer is under the control of a gene, the expression of which involves positive feedback. The following figure shows the various components of this system (Ref. 1).
