Virginia Tech

From 2007.igem.org

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The Virginia Tech iGEM project for 2007 is to engineer an epidemic. This will allow us to model and observe epidemic development within and between populations. By modeling and observing epidemic development, we hope to be able to understand events from the beginning of an epidemic. We will be able to do this by designing a network for the spread of infection. Our model will be multi-scaled and will include modeling a bacterial growth curve, modeling an infection of a single population, and modeling a muliple population infection. After developing the models, we will be able to verify it experimentally.
 
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Our project is particularly important because it is important to be able to predict early whether or not an infection will develop into an epidemic. It is important to know how to localize an infection to prevent the development of an epidemic. By modeling and experimentally testing the effects of air traffic on an epidemic, we can determine at what point an infection becomes an epidemic.  
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'''<html><center><font size="5" color="#8b0000">The 2007 Virginia Tech iGEM team welcomes you to our Wiki! </font><br><br><font size="4">Look around to learn about our 2007 project: Engineering an Epidemic.</font></center></html>'''
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After matching our models to our experimental data, we hope to be able to publish some of our findings.  
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[[Image:InfectionMatch.png|thumb|300px|center|'''Matching infection in a single population.''' Go to our
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[[Virginia_Tech/model|modeling page]] to learn more.]]
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<html><center></html><h3>Modeling and Epidemiology</h3>
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This year, our team worked on engineering an epidemic by simulating the spread of an infection in a biological model system. Our model has multiple levels, which we matched to experimental data one at a time. Click [[Virginia_Tech/model|here]] to read more about our modeling experience.<html></center></html>
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[[Image:Ecoli phage.PNG|thumb|center|350px|'''''E.coli'' infected with fluorescent phage.''' This cell is lytic: the green spots are new phage particles being constructed prior to lysis.]]
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<html><center></html><h3>Using a Biological Model System</h3>
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λ phage and ''E. coli'' constitute our model system. λ phage has two infection pathways: lysis and lysogeny. A lytic cell will burst shortly after infection, while a lysogenic cell stays dormant. In order to find out which pathway had been chosen in our bacteria, we constructed a [[Virginia_Tech/plasmid_design|reporter plasmid]].<html></center></html>
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Revision as of 20:44, 24 October 2007

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This wiki is under construction! While you’re waiting, check out our externally hosted wiki here.

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The 2007 Virginia Tech iGEM team welcomes you to our Wiki!

Look around to learn about our 2007 project: Engineering an Epidemic.


Matching infection in a single population. Go to our modeling page to learn more.

Modeling and Epidemiology

This year, our team worked on engineering an epidemic by simulating the spread of an infection in a biological model system. Our model has multiple levels, which we matched to experimental data one at a time. Click here to read more about our modeling experience.
E.coli infected with fluorescent phage. This cell is lytic: the green spots are new phage particles being constructed prior to lysis.

Using a Biological Model System

λ phage and E. coli constitute our model system. λ phage has two infection pathways: lysis and lysogeny. A lytic cell will burst shortly after infection, while a lysogenic cell stays dormant. In order to find out which pathway had been chosen in our bacteria, we constructed a reporter plasmid.



We would like to thank our sponsors:




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