Cell Integration
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== Cell Integration == | == Cell Integration == | ||
| - | Increased levels or strength of adherins will cause cells to penetrate into tissue with lower levels of cell-cell interacting molecules. Activation of signaling by binding of one of our signaling targeting chimeric proteins will trigger expression of N- | + | Increased levels or strength of adherins will cause cells to penetrate into tissue with lower levels of cell-cell interacting molecules. Activation of signaling by binding of one of our signaling targeting chimeric proteins will trigger expression of the cell-cell adhesion molecule N-Cadherin which was inserted downstream of a minimal promoter with lexA operators. Increased N-Cadherin expression may result in penetration of the new cardiomyocytes into the myocardium. |
| + | Ilustrative data demonstrating the basic principle from the literature: | ||
[[Image:adherins.gif]] | [[Image:adherins.gif]] | ||
Latest revision as of 04:12, 27 October 2007
Cell Integration
Increased levels or strength of adherins will cause cells to penetrate into tissue with lower levels of cell-cell interacting molecules. Activation of signaling by binding of one of our signaling targeting chimeric proteins will trigger expression of the cell-cell adhesion molecule N-Cadherin which was inserted downstream of a minimal promoter with lexA operators. Increased N-Cadherin expression may result in penetration of the new cardiomyocytes into the myocardium.
Ilustrative data demonstrating the basic principle from the literature:
