Bangalore

From 2007.igem.org

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|On June 1st 2007, a group of undergraduates of various disciplines and from around the country assembled at NCBS, to attempt a 'proof of principle' demonstration. Their mission: to assemble and test a 'genetically engineered machine', a complex network assembled from simple biological parts. You will be amazed how much they managed to achieve in just six weeks!
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''The National Centre for Biological Sciences is a research institute located in Bangalore, India. In 2006, a team of graduate students from NCBS was the first from India to participate in iGEM. This year, we are very excited to compete as an all-undergraduate team of six students, from six different colleges located in four cities around India. Now that the summer is over, we hope to take the excitement of iGEM back to our home institutions, and create new teams across India who will participate in future iGEMs.''
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|align="center"|[http://www.ncbs.res.in/ National Centre for Biological Sciences, Bangalore]
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<!--- The Mission, Experiments --->
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== '''The Company''' ==
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{| style="color:#294e9c;background-color:#e1e0db;" cellpadding="3" cellspacing="1" border="1" bordercolor="#1100ff" width="62%" align="center"
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!align="center"|[[Bangalore|Home]]
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!align="center"|[[The Team|The Team]]
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!align="center"|[[The Goal|The Goal]]
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!align="center"|[[Parts Data Sheets|Parts Data Sheets]]
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!align="center"|[[Mathematical Models|Mathematical Models]]
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!align="center"|[[e-Notebook|e-Notebook]]
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*Mukund:    Chief Mentor, Consultant and The Godfather
 
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*Sugat:      Right-hand Man and Manager of Operations
 
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*Nilesh:    The Man for all Seasons 
 
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*Vivek:     Chief Troubleshooter, often his role is confused with one of a Troublemaker
 
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*Krishna:    The Sharpshooter
 
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*Senthil:    The Wikiman, also fondly referred to as the "Bio Info God"
 
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*Varun:      The Voice of Reason and Anti-Reason
 
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*K12Z1:      The Workhorse
 
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== '''The Mission''' ==
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[[Image:timeline.png|center|]]
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To investigate multistability and hysteresis in combinatorially constructed synthetic ''Vibrio'' quorum sensing circuits
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== ==
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== '''The Target - Vibrio Quorum Sensing System''' ==
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Quorum sensing is a phenomenon by which bacteria sense a critical cell density before turning on the expression of certain genes. It involves the gradual build-up of a chemical termed the 'autoinducer' in the cell. The autoinducer freely diffuses across the cell membrane and hence, its concentration is population density dependent. When the concentration crosses a threshold, the bacteria switch to a different physiological state such as bioluminescence, virulent gene expression, and bio-film formation.
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[[Image:igem_bangalore_07.jpg|thumb|550px|center|<font color="green">'''Top to Bottom''':</font><font color="black"> Navneet, Nilesh, Vivek, Vini, Krishna, Varun, E.coli, Shashanka, Mukund, Senthil and Sushant at the NCBS Amphitheatre.</font>]]
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</font>
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In Vibrio fischeri, when the population density (and hence the concentration of autoinducer) crosses a certain threshold, the expression of a set of genes that is required for bioluminescence is turned on. The production of the autoinducer is under the control of a gene, the expression of which involves positive feedback. The following figure shows the various components of this system (Ref. 1).
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Latest revision as of 07:20, 24 October 2007

On June 1st 2007, a group of undergraduates of various disciplines and from around the country assembled at NCBS, to attempt a 'proof of principle' demonstration. Their mission: to assemble and test a 'genetically engineered machine', a complex network assembled from simple biological parts. You will be amazed how much they managed to achieve in just six weeks!
Ncbs Logo.jpg

The National Centre for Biological Sciences is a research institute located in Bangalore, India. In 2006, a team of graduate students from NCBS was the first from India to participate in iGEM. This year, we are very excited to compete as an all-undergraduate team of six students, from six different colleges located in four cities around India. Now that the summer is over, we hope to take the excitement of iGEM back to our home institutions, and create new teams across India who will participate in future iGEMs.

Ncbs.jpg
[http://www.ncbs.res.in/ National Centre for Biological Sciences, Bangalore]


Home The Team The Goal Parts Data Sheets Mathematical Models e-Notebook


Timeline.png

Top to Bottom: Navneet, Nilesh, Vivek, Vini, Krishna, Varun, E.coli, Shashanka, Mukund, Senthil and Sushant at the NCBS Amphitheatre.

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