From 2007.igem.org
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| - | Our project for iGEM 2007 involves modeling the dynamics of the spread of an epidemic within a population. The model will be multiscale, specifically covering the molecular biology of the phage-host interaction, the spread of the phage within an isolated subpopulation, and the spread of the phage between artificially connected
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| - | subpopulations. Integrating these levels of modeling to produce varying high-level population epidemic behavior by
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| - | changing, for example, promoter strengths for the production of relevant proteins is one of the key aspects of our
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| - | project. Building an understanding of high-level dynamics from the very lowest level of organization will
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| - | demonstrate our ability to more accurately predict the epidemiological outcome.
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| - | For our host and phage we will use E. Coli and lambda phage respectively. We select this host-phage pair because
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| - | they are both so well understood and documented and therefore we can more easily model their interaction,
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| - | particularly at the molecular level. Lambda phage is also interesting because it can either immediately replicate
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| - | itself and kill the host cell or it can insert its DNA and lie dormant. This adds a degree of flexibility to our
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| - | model that allows us to check the model robustness for slightly different phage. As part of the project we have
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| - | designed a reporter plasmid to generate florescent proteins to indicate which pathway the virus has taken. This
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| - | plasmid, along with the use of a phage modified to be florescent, will allow us to determine how the population acts
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| - | and verify our models.
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| - | At the highest level of our modeling we will use air traffic data with 96-well plates and a liquid handling
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| - | system to indicate how a virus might spread via air traffic. Since a person can now get around the world before a
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| - | virus manifests symptoms, this information is relevant to epidemiological studies. Using this model we can examine
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| - | how shutting down certain airports or groups of airports might help to limit or prevent the spread of a virus
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| - | through air travel.
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Revision as of 18:55, 22 May 2007
This page needs to be moved to your team's pages. It is not a Project Description for all of iGEM. It should have a name like
MYTEAM/Project Description
