Bangalore
From 2007.igem.org
(→'''The Company''') |
(→'''The Company''') |
||
| Line 3: | Line 3: | ||
| - | *Mukund: | + | *<nowiki>Mukund: Chief Mentor, Consultant and The Godfather</nowiki> |
| - | *Sugat Right-hand Man and Manager of Operations | + | *Sugat: Right-hand Man and Manager of Operations |
| - | *Nilesh | + | *Nilesh: The Man for all Seasons |
| - | *Vivek Chief Troubleshooter, often his role is confused with one of a Troublemaker | + | *Vivek: Chief Troubleshooter, often his role is confused with one of a Troublemaker |
| - | *Krishna: | + | *Krishna: The Sharpshooter |
| - | *Senthil: | + | *Senthil: The Wikiman, also fondly referred to as the "Bio Info God" |
| - | *Varun: | + | *Varun: The Voice of Reason and Anti-Reason |
| - | *K12Z1: | + | *K12Z1: The Workhorse |
== The Mission == | == The Mission == | ||
Revision as of 07:30, 29 May 2007
The Company
- Mukund: Chief Mentor, Consultant and The Godfather
- Sugat: Right-hand Man and Manager of Operations
- Nilesh: The Man for all Seasons
- Vivek: Chief Troubleshooter, often his role is confused with one of a Troublemaker
- Krishna: The Sharpshooter
- Senthil: The Wikiman, also fondly referred to as the "Bio Info God"
- Varun: The Voice of Reason and Anti-Reason
- K12Z1: The Workhorse
The Mission
To investigate multistability and hysteresis in combinatorially constructed synthetic Vibrio quorum sensing circuits
The Target - Vibrio Quorum Sensing System
Quorum sensing is a phenomenon by which bacteria sense a critical cell density before turning on the expression of certain genes. It involves the gradual build-up of a chemical termed the 'autoinducer' in the cell. The autoinducer freely diffuses across the cell membrane and hence, its concentration is population density dependent. When the concentration crosses a threshold, the bacteria switch to a different physiological state such as bioluminescence, virulent gene expression, and bio-film formation.
In Vibrio fischeri, when the population density (and hence the concentration of autoinducer) crosses a certain threshold, the expression of a set of genes that is required for bioluminescence is turned on. The production of the autoinducer is under the control of a gene, the expression of which involves positive feedback. The following figure shows the various components of this system (Ref. 1).
