Paris/Modeling
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We present here a theoretical approach based on population dynamics. We consider here the case of a well mixed, homogeneous, culture of the SMB organism, i.e. there is no space in this analysis and we follow only the variation of the different cell lines concentrations in the culture volume. | We present here a theoretical approach based on population dynamics. We consider here the case of a well mixed, homogeneous, culture of the SMB organism, i.e. there is no space in this analysis and we follow only the variation of the different cell lines concentrations in the culture volume. | ||
| - | ==[[Paris/Cell_auto| | + | ==[[Paris/Cell_auto|Simple automaton]]== |
We want with this work to characterize the diffusion of the DAP and the effect on the cells. We have a lawn of bacterias with germinal cells and some somatic cells. | We want with this work to characterize the diffusion of the DAP and the effect on the cells. We have a lawn of bacterias with germinal cells and some somatic cells. | ||
Revision as of 14:07, 24 October 2007
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Contents |
Introduction
Macroscopic Models
Those models are at macroscopic scale. They are focused on the evolution of the population, with global rules avoiding description of all the microscopic mechanisms. We present tree different works, with different approaches (ODE, automaton)...
Differential
We present here a theoretical approach based on population dynamics. We consider here the case of a well mixed, homogeneous, culture of the SMB organism, i.e. there is no space in this analysis and we follow only the variation of the different cell lines concentrations in the culture volume.
Simple automaton
We want with this work to characterize the diffusion of the DAP and the effect on the cells. We have a lawn of bacterias with germinal cells and some somatic cells.
Complex automaton
We try with this model to see the effect of DAP on the cells. We have a growing culture with germinal cells and somatic cells. We want to see if we can have different kinds of evolution for our cells. as we can see in the simple automaton the diffusion mechanism and the effect on differentiation can be describe more accurately, so for the moment we just ignore the diffusion putting a black box on it and just focused on the total number of DAP entities.
Microscopic Models
Those models are at microscopic scale. They are focused on the description of the microscopic mechanisms like exportation, diffusion, mechanism of differentiation... We present two different works, with different approaches (ODE, Gillespie)...
Differential
This model aims at describing the dynamic evolution of populations of germen and soma type bacteria. It is based on a set of differential equations describing DAP synthesis, DAP transport, differentiation of germen bacteria into soma and bacteria death. This approach differs form the precedents one by the level of description of the model and the numerical analysis done on the model.
Stochastic
Conclusion
Tools
For our simulations we used unusual tools, Biocham and MGS. Thanks to their specificities and capacities, we were able to simulate easily the mechanisms that we wanted to focus on.
Biocham
MGS
