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Cellular Lead Sensor
Lead poisoning is a public health concern - there is lead in soil, paint, water, and dust. Lead Poisoning is often caused by ingesting contaminated drinking water, or soil. It can cause neurological and gastrointestinal disorders, especially among children.
The legal limit of lead in drinking water is 15 parts per billion.
Current ways of testing for lead either require expensive chemical lab analysis or involve inaccurate home kits.
A lead detector, based on E. Coli, is cheap, sensitive, quick, and specific
Our system involves a Lead detecting promoter, an amplifier, and an output of GFP. We're also working on a system to remove false positives.
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Tristable Switch
Wouldn't you like to have a stable signal in the continuously fluctuating environment of cells?
And if, say, your system doesn't work the very first try, wouldn't you like to have a methodical means to go about debugging it?
The Tri-Stable Toggle Switch represents a continuation on the theme of the Toggle Switch begun by Gardner, et al to produce stable outputs in response to transient inputs. Our novel approach to the Tri-Stable Switch design is founded on quantitative principles, pioneering a technique to remove the guesswork from designing and debugging biological systems.
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