BerkiGEM2007Present4
From 2007.igem.org
Immunity
Inserting most wild-type E. coli into a human system causes rapid sepsis, an undesirable effect that we have eliminated. We have modified carbohydrate markers of our base strain to permit insertion into the bloodstream.
Introduction
White blood cells constantly roam the bloodstream in search of foreign bodies. The human immune system targets potentially infectious bacteria by membrane signature and the presence of antigens (PLEASE ADD CLEAR INFO HERE CHRIS, LIKE THE VERY FIRST INTRO POWERPOINT YOU SHOWED US). Some bacteria, however, are able to evade detection. Our bacteria mimics these characteristics.
O1 Antigen
Salmonella includes this antigen. It allows it to effectively enter humans. We have integrated this gene, known as wbbL (? i hope this is right), into the genome of our bacteria.
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K Capsule
MR. STRAIN possesses a carbohydrate capsule which further prevents recognition by the human immune system. We have also cloned this gene into our bacteria genome.
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