Introduction
????Blurb about BOL????These are the projects we are undertaking this year:
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Standardising the Agr signalling system
The Accessory Gene Regulator (Agr) system in S. aureus is an oligopeptide-based quorum sensing mechanism. We aim to convert it into a reusable interbacterial signalling system for communication amongst and between both Gram-positive species (B. subtilis) and Gram-negative bacteria (E. coli), based on controllable secretion and detection of the signalling peptide AIP.
For more information, see Signalling project description.
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Bacillus subtilis SynBio Chassis
Most synthetic biology so far has involved Gram-negative bacteria, which are more widely used in molecular biology research; however, the biotechnology industry relies on Gram-positive bacteria. We are trying to make a "chassis" out of Bacillus subtilis, a common Gram-positive bacterium, into which genetic engineers can add BioBrick parts and control circuits.
For more information, see Bacillus subtilis SynBio chassis
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PoPS amplifier
We aim to build a standard amplifier which can be used in any synthetic (BioBricked) system, which would take in a standard PoPS input and give a PoPS output of a known amplification factor.
For more details, have a look at the amplifier project.
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????LINK TO CCBI WIKI For full details
????Link to our team page on Registry
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Meet the team!
Front row, from left: Narin Hengrung, Yi Han, David Wyatt
Second row, from left: Zhizhen Zhao (Jane), Stefan Milde, Dmitry Malyshev, Xinxuan Soh (Sheila)
Third row, from left: Yi Jin Liew, John Crowe (faculty), Lovelace Soirez, Stephanie May, Yue Miao
Back row, from left: James Brown (PhD student mentor), Jim Haseloff (faculty supervisor), Gos Micklem (faculty supervisor)
Not in photo: Jim Ajioka (faculty supervisor), Lorenz Wernisch (faculty), Tony Southall (PhD student)
The mailing list for the whole Cambridge iGEM2007 team is igem2007 [at] ccbi.cam.ac.uk
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