Talk:Tokyo/Model

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==E.coli Follows Pareto's principle! ==
==E.coli Follows Pareto's principle! ==
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''' To follow Pareto’s principle like an [[Tokyo/Concepts|ant society]], our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of state A (worker) or B (idler) depending on the surrounding circumstances. They change their states as if they DIFFERENTIATE so that the ratio of the two cell states is well balanced.
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''' To follow Pareto’s principle found in an [[Tokyo/Concepts|ant society]], our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of state A (worker) or B (idler) depending on the surrounding circumstances. They change their states as if they DIFFERENTIATE so that the ratio of the two cell states is well balanced.
''' ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])
''' ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])
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'''Bistable state ⇒ The removal of A (worker) ⇒ Unstable state with only B left ⇒ Balanced Redifferentiation of B (idlers)'''
'''Bistable state ⇒ The removal of A (worker) ⇒ Unstable state with only B left ⇒ Balanced Redifferentiation of B (idlers)'''
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[[Image:1state.JPG|thumb|210px|'''Fig. 1 Condition 1. Bistable state at balanced ratio of two types''' <br>The system is stable when it contains both A (worker) and B (idler) "balanced" at certain ratio.|left]]
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[[Image:1state.JPG|thumb|210px|'''Fig. 1 Condition 1. Bistable state at balanced ratio of differentiated A and B''' <br>The system is stable when it contains both A (worker) and B (idler) "balanced" at certain ratio.|left]]
[[Image:2state.JPG|thumb|190px|'''Fig. 2 Condition 2. Removal of A''' <br>Now that A (worker) is removed, there is only B (idler) left.|center|left]]
[[Image:2state.JPG|thumb|190px|'''Fig. 2 Condition 2. Removal of A''' <br>Now that A (worker) is removed, there is only B (idler) left.|center|left]]
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[[Image:3state.JPG|thumb|190px|'''Fig. 3 Condition 3. Unstable B''' <br>While after the removal of A (worker), B becomes unstable and ''dedifferentiates''.|center|left]]
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[[Image:3state.JPG|thumb|190px|'''Fig. 3 Condition 3. Dedifferentiation of B''' <br>While after the removal of A (worker), B (idler) becomes unstable and ''dedifferentiates''.|center|left]]
<!--Node B detects the removal of node A from the system and knows that there is only node B left.-->  
<!--Node B detects the removal of node A from the system and knows that there is only node B left.-->  
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[[Image:4state.JPG|thumb|210px|'''Fig. 4 Condition 4. Balanced Redifferentiation''' <br>Some B (idler) ''redifferentiate'' into A (worker) while the others remain B (idler). Then the system becomes stable again with the balanced ratio of A and B.|center|left]]
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[[Image:4state.JPG|thumb|210px|'''Fig. 4 Condition 4. Balanced Redifferentiation''' <br>Some Dedifferentiated cells ''redifferentiate'' into A (worker) while the others go back to B (idler). Then the system becomes stable again with the balanced ratio of A and B.|center|left]]
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Latest revision as of 18:43, 26 October 2007

E.coli Follows Pareto's principle!

To follow Pareto’s principle found in an ant society, our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of state A (worker) or B (idler) depending on the surrounding circumstances. They change their states as if they DIFFERENTIATE so that the ratio of the two cell states is well balanced. ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])



As shown in Fig. 1, 2, 3, and 4, the condition of the system is changing as follows:

Bistable state ⇒ The removal of A (worker) ⇒ Unstable state with only B left ⇒ Balanced Redifferentiation of B (idlers)

Fig. 1 Condition 1. Bistable state at balanced ratio of differentiated A and B
The system is stable when it contains both A (worker) and B (idler) "balanced" at certain ratio.
Fig. 2 Condition 2. Removal of A
Now that A (worker) is removed, there is only B (idler) left.
Fig. 3 Condition 3. Dedifferentiation of B
While after the removal of A (worker), B (idler) becomes unstable and dedifferentiates.
Fig. 4 Condition 4. Balanced Redifferentiation
Some Dedifferentiated cells redifferentiate into A (worker) while the others go back to B (idler). Then the system becomes stable again with the balanced ratio of A and B.