Tokyo/Model

From 2007.igem.org

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==[[Tokyo_Tech|Abstract]]  [[Tokyo/Model|Concept & Model]]  [[Tokyo/Requirements |Requirements]]  [[Tokyo/Genetic circuit|Genetic_circuit]]  [[Tokyo/Works|Works]]  [[Tokyo/About our team|About_our_team]]==
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==Balanced Redifferentiation of E.coli ! ==
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<!--==パレートの法則にしたがった大腸菌の振る舞いとは?==-->
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''' To follow Pareto’s principle found in an [[Tokyo/Concepts|ant society]], our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of stable state A (worker) or B (idler) depending on the surrounding circumstances as if they are DIFFERENTIATE. They also change their states as if they DEDIFFERENTIATE and REDIFFERENTIATE so that the ratio of the two cell states is well balanced.
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''' ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])
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==E.coli Follows Pareto's principle! ==
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''' To follow Pareto’s principle like an [[Tokyo/Concepts|ant society]], our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of state A (worker) or B (idler) depending on the surrounding circumstances. ''' ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])
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<br>'''As shown in Fig. 1, 2, 3, and 4, the condition of the system is changing as follows:'''<br><br>
<br>'''As shown in Fig. 1, 2, 3, and 4, the condition of the system is changing as follows:'''<br><br>
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'''Bistable state ⇒ The removal of A (worker) ⇒ Unstable state with only B left Regain of "stable coexistence"'''
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'''Bistable state ⇒ The removal of A (worker) ⇒ Dedifferentiation of B(idlers)Balanced Redifferentiation into A and of B'''
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[[Image:1state.JPG|thumb|190px|'''Fig. 1 Condition 1. Bistable state''' <br>The system is stable when it contains both A (worker) and B (idler) at certain ratio.|left]]
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[[Image:1state.JPG|thumb|210px|'''Fig. 1 Condition 1. Bistable state at balanced ratio of differentiated A and B''' <br>The system is stable when it contains both A (worker) and B (idler) "balanced" at certain ratio.|left]]
[[Image:2state.JPG|thumb|190px|'''Fig. 2 Condition 2. Removal of A''' <br>Now that A (worker) is removed, there is only B (idler) left.|center|left]]
[[Image:2state.JPG|thumb|190px|'''Fig. 2 Condition 2. Removal of A''' <br>Now that A (worker) is removed, there is only B (idler) left.|center|left]]
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[[Image:3state.JPG|thumb|190px|'''Fig. 3 Condition 3. Unstable B''' <br>While after the removal of A (worker), B becomes unstable and "stable coexistence" of the system is broken.|center|left]]
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[[Image:3state.JPG|thumb|190px|'''Fig. 3 Condition 3. Dedifferentiation of B''' <br>While after the removal of A (worker), B (idler) becomes unstable and ''dedifferentiates''.|center|left]]
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<!--Node B detects the removal of node A from the system and knows that there is only node B left.-->  
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[[Image:4state.JPG|thumb|190px|'''Fig. 4 Condition 4. Regain of "stable coexistence"''' <br>Some B (idler) changes to A (worker) while the others remain B (idler). Then the system regains "stable coexistence".|center|left]]
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[[Image:4state.JPG|thumb|210px|'''Fig. 4 Condition 4. Balanced Redifferentiation''' <br>Some Dedifferentiated cells ''redifferentiate'' into A (worker) while the others go back to B (idler). Then the system becomes stable again with the balanced ratio of A and B.|center|left]]
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Revision as of 18:50, 26 October 2007

Balanced Redifferentiation of E.coli !

To follow Pareto’s principle found in an ant society, our model system must satisfy the three conditions shown in Fig. 1 to 4. In our model, all individual cells have the same genetic circuits but take either of stable state A (worker) or B (idler) depending on the surrounding circumstances as if they are DIFFERENTIATE. They also change their states as if they DEDIFFERENTIATE and REDIFFERENTIATE so that the ratio of the two cell states is well balanced. ([http://en.wikipedia.org/wiki/Pareto_principle What is Pareto's principle? (Wikipedia)])



As shown in Fig. 1, 2, 3, and 4, the condition of the system is changing as follows:

Bistable state ⇒ The removal of A (worker) ⇒ Dedifferentiation of B(idlers)⇒ Balanced Redifferentiation into A and of B

Fig. 1 Condition 1. Bistable state at balanced ratio of differentiated A and B
The system is stable when it contains both A (worker) and B (idler) "balanced" at certain ratio.
Fig. 2 Condition 2. Removal of A
Now that A (worker) is removed, there is only B (idler) left.
Fig. 3 Condition 3. Dedifferentiation of B
While after the removal of A (worker), B (idler) becomes unstable and dedifferentiates.
Fig. 4 Condition 4. Balanced Redifferentiation
Some Dedifferentiated cells redifferentiate into A (worker) while the others go back to B (idler). Then the system becomes stable again with the balanced ratio of A and B.