USTC

Our Project:
Extensible Logic Circuit in Bacteria

Logic Artificial Biological Circuit (ABC) and logic Integrated Circuit (IC) are both composed by "components" and "wires". Though we have been enjoying the advantages of Ultra Large Scale IC (ULSI) in modern life, we still cannot implement in biological experiments a somewhat large-scale logic ABC with several levels of logic gates in it.

Our project is to provide a new method for building up a fully extensible logic ABC. For some biological convenience, we are going to produce such biological logic gates as NAND, NOR, NOT which are exactly the basis for modern logic IC. More importantly, several factors influence the scale of ABC and IC, such as, the size and power of the components, the interference between wires, and standardization of intercommunication. Cis-acting components in ABC may present a smaller scale and power request than trans-acting ones, while the other two factors can be improved by novelly-designed and calibrated wires. We are also going to demonstrate an ABC made by these biological logic gates and wires.

Such an ABC may not be large, but the important factors we implement in it will naturally make it fully extensible. IC has existed for 50 years, and now how huge its impact is on our modern lives! Then what about the biological logic circuits in the next 50 years? A new world is waiting...

From left to right
Back row: Zhao Yun, Liu ZQ, Ma XY
Front row: Ma Rui, Su XF, Ding Bo, Zhan Jian

Project

Introduction

Core Logic Components:

Logic-Gate Promoters

Wires without Interference:

Repressor Evolution on Plates

Repressor Evolution in Silico

Peripheral Devices:

Inputs and Outputs

Extensible System:

A Demonstration

Further More

Events

19/09/2007
We are pummeled by [http://news.yahoo.com/s/ap/20070919/ap_on_re_as/asia_typhoon Typhoon Wipha]. Most of our service providers suspend their work. What a sad day!

18/09/2007
Draft of our schedule for the Jamboree.

04/09/2007
The second scheme of NAND gate has been built up and the rough data show that it works. More precise quantitative data is to be measured.

02/09/2007
Double-reporters system version 2 has passed sequencing, and been confirmed by X-gal assay and fluorescence observation.

Previous

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Laboratory

[http://sg.ustc.edu.cn/mediawiki/index.php/IGEM_USTC_2007:USTCPhotos USTC Photos]

[http://sg.ustc.edu.cn/mediawiki/index.php/IGEM_USTC_2007:HuangshanPhotos Huangshan Mountain]

Links

[http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=USTC Parts Made by USTC iGEM 2007]

[http://partsregistry.org iGEM Standard Parts' Catalog ]

IGEM2007 Team List

[http://www.ustc.edu.cn Univ. of Sci. and Tech. of China ]