The SMB: Synthetic Multicellular Bacterium

The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

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For your convenience, download a printable pdf version of our wiki.

Going through our wiki


Student Members

Aurélien Rizk
David Bikard
David Guegan
David Puyraimond
Eimad Shotar
Fanny Caffin
Gilles Vieira
Nicolas Chiaruttini
Thomas Clozel
Thomas Landrain


Ariel Lindner
Alfonso Jaramillo
Franck Delaplace
Francois Kepes
Vincent Schachter
Samuel Bottani


Antoine Spicher
Francois Le Fevre
Pablo Tortosa
Maria Suarez
Serge Smidtas


Site Map


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Below, our wiki pages during work in summer 2007.

Life in the Lab

The team at work

From October 17th 2007:
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We are extremely grateful to the following organisations for their support of our project:

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Fondation Bettencourt


Ambassade de France aux Etats Unis