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-	<font size=20>This page is under construction</font><br><br>	+	== <center>The SMB: Synthetic Multicellular Bacterium</center> == <br>
		+	The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems.  It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.
-	Il faudrait mettre ici un abstract digne de ce nom... En attendant, je laisse ca...
-		+	{{Paris_video_modeling2}}
-	The idea is to make a multicellular organism out of bacteria. This simple organism will have two distinct types of cells. The first one would be the germ line, the other one the soma. The germ line will be auxotroph for a given nutriment, which will be provided by the soma. The soma will differentiate from the germ line and will be unable to divide. In this way, there is a need for a part of the germ line to differentiate into soma in order to feed the rest of the germ line Hence, the soma doesn't exist without a germ line to generate it.	+

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Latest revision as of 12:42, 25 October 2007

== The SMB: Synthetic Multicellular Bacterium ==

The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

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