Paris

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Revision as of 20:59, 26 October 2007

The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

Members Student Members Aurélien Rizk David Bikard David Guegan David Puyraimond Eimad Shotar Gilles Vieira Nicolas Chiaruttini Thomas Clozel Thomas Landrain Instructors Ariel Lindner Alfonso Jaramillo Franck Delaplace Francois Kepes Vincent Schachter Samuel Bottani Advisors Chafika Chettaoui| Antoine Spicher Francois Le Fevre Pablo Tortosa Maria Suarez Serge Smidtas

Informations Summary of the teachers workshop Schedule Links [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)] [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology] [http://partsregistry.org/Main_Page The registry] [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials] [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide]

Project Project Description Life in the Lab Molecular biology constructs Team Notebook Oligos Protocols Freezer [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry] Forum The team at work

From October 17th 2007:


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We are extremely grateful to the following organisations for their support of our project:

Fondation Bettencourt [http://www.fondationbs.org/ www.fondationbs.org] Sofinnova [http://www.sofinnova.fr www.sofinnova.fr] Ambassade de France aux Etats Unis [http://www.ambafrance-us.org/ www.ambafrance-us.org] Synbiocomm [http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]