Paris

From 2007.igem.org

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<font size=14><center>The SMB: Synthetic Multicellular Bacterium</center></font> <br>
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{{Paris_MainMenu}}
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The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.
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{{paris_video_modeling2}}
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For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of  our wiki.
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----
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<center>'''[[Going through our wiki|Going through our wiki]]'''</center>
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<center><h3>Members</h3>
<center><h3>Members</h3>
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[[User:Davidpz|David Puyraimond]]<br>
[[User:Davidpz|David Puyraimond]]<br>
[[User:Eismoustique|Eimad Shotar]]<br>
[[User:Eismoustique|Eimad Shotar]]<br>
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[[User:Fanny.c|Fanny Caffin]]<br>
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[[User:fanny.c|Fanny Caffin]]<br>
[[User:Vieira|Gilles Vieira]]<br>
[[User:Vieira|Gilles Vieira]]<br>
[[User:Nicolas C.|Nicolas Chiaruttini]]<br>
[[User:Nicolas C.|Nicolas Chiaruttini]]<br>
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[[User:Malicia|Rayna Stamboliyska]]<br>
 
[[User:Thomasclozel|Thomas Clozel]]<br>
[[User:Thomasclozel|Thomas Clozel]]<br>
[[User:Landrain|Thomas Landrain]]<br>
[[User:Landrain|Thomas Landrain]]<br>
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'''Advisors'''
'''Advisors'''
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[[User:Chettaoui|Chafika Chettaoui|]]<br>
 
[[User:Spicher|Antoine Spicher]]<br>
[[User:Spicher|Antoine Spicher]]<br>
[[User:flefevre|Francois Le Fevre]]<br>
[[User:flefevre|Francois Le Fevre]]<br>
[[User:PTortosa|Pablo Tortosa]]<br>
[[User:PTortosa|Pablo Tortosa]]<br>
[[User:maria|Maria Suarez]]<br>
[[User:maria|Maria Suarez]]<br>
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[[User:SMIDTAS|Serge Smidtas]]<br>
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<center><h3>Informations</h3></center>
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<center><h3>Information</h3></center>
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<br><br>
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'''Site Map'''
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'''[[Summary of the teachers|Summary of the teachers workshop]] '''
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*[[Paris|Main Page]]
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<br><br>
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*[[Paris/Introduction|Introduction]]
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*[[Paris/DesignProcess |Design Process]]
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*[[Paris/Modeling|Modeling]]
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*[[Paris/ConstructionProcess |Construction Process]]
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*[[Paris/Results|Results]]
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*[[Paris/Perspectives|Perspectives]]
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*[[Paris/Acknowledgments|Acknowledgments]]
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'''Schedule'''
 
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* '''Next meeting : Thursday october 4th'''
 
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Special session on modelling and organization of the wiki
 
<br><br>
<br><br>
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'''Links'''
'''Links'''
* [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
* [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
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* [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology]
* [http://partsregistry.org/Main_Page The registry]
* [http://partsregistry.org/Main_Page The registry]
* [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
* [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
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<br><br><br>
<br><br><br>
<center>[[Image:Tour eiffel.gif|60px]]</center>
<center>[[Image:Tour eiffel.gif|60px]]</center>
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<center><h3>Project</h3></center>
<center><h3>Project</h3></center>
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* '''[[Paris/Project Description| Project Description]]'''
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<br>
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* [[Paris/Project Description| Project Description]]
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''Below, our wiki pages during work in summer 2007.''
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* [[Paris/Modeling| Modeling]]
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'''Life in the Lab'''
'''Life in the Lab'''
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* [[Paris/Constructs| Molecular biology constructs]]
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* [[Paris/What's going on in the lab|What's going on in the lab ?]]
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* [[Paris/Notebook_Calendar| Team Notebook]]
* [[Paris/Notebook_Calendar| Team Notebook]]
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From October 17th 2007:<br>
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<a href="http://www3.clustrmaps.com/counter/maps.php?url=https://2007.igem.org/Paris" id="clustrMapsLink"><img src="http://www3.clustrmaps.com/counter/index2.php?url=https://2007.igem.org/Paris" style="border:0px;" alt="Locations of visitors to this page" title="Locations of visitors to this page" id="clustrMapsImg" onError="this.onError=null; this.src='http://www2.clustrmaps.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://www2.clustrmaps.com'" />
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</a>
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<br>
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<a href="http://www.easycounter.com/">
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<img src="http://www.easycounter.com/counter.php?dbikard"
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border="0" alt="Web Counters"></a>
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<br><a href="http://www.easycounter.com/FreeCounter3.html">Hit Counters</a>
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</html>
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We are extremely grateful to the following organisations for their support of our project:
We are extremely grateful to the following organisations for their support of our project:
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<table><tr><td>
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| [http://www.syntheticbiology.ethz.ch/synbiocomm/index https://static.igem.org/mediawiki/2007/8/8f/Synbiocomm.jpg]
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| [http://www.ambafrance-us.org/ http://www.ambafrance-us.org/images/gr_logo.jpg]
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</td><td>
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[[Image:Paris_Sponsors.jpg]]
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| [[Image:Paris_FBS.jpg]] <br> [http://www.fondationbs.org/ Fondation Bettencourt]
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</td><td>
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| [http://www.sofinnova.fr/scripts/ Sofinnova]
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Fondation Bettencourt
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[http://www.fondationbs.org/ www.fondationbs.org]
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Sofinnova
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[http://www.sofinnova.fr www.sofinnova.fr]
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Ambassade de France aux Etats Unis
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[http://www.ambafrance-us.org/ www.ambafrance-us.org]
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Synbiocomm
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[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]
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</td></tr></table>
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[[Image:IGEMteam5.jpg|920px|center]]

Latest revision as of 03:10, 27 October 2007

ParisLogoIGEM.jpg
The SMB: Synthetic Multicellular Bacterium



The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.


modeling <object style="width:640px;height:480px"> <param name="movie" value="http://biosynthetique.free.fr/videos/flv_player/flvplayer.swf?image=http://biosynthetique.free.fr/photo/01.jpg&amp;autostart=false&amp;file=http://biosynthetique.free.fr/videos/finalv4.flv" /> <param name="quality" value="high" /> </object>

For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of our wiki.

Going through our wiki


Members

Student Members

Aurélien Rizk
David Bikard
David Guegan
David Puyraimond
Eimad Shotar
Fanny Caffin
Gilles Vieira
Nicolas Chiaruttini
Thomas Clozel
Thomas Landrain


Instructors

Ariel Lindner
Alfonso Jaramillo
Franck Delaplace
Francois Kepes
Vincent Schachter
Samuel Bottani

Advisors

Antoine Spicher
Francois Le Fevre
Pablo Tortosa
Maria Suarez
Serge Smidtas

Information

Site Map




Links

  • [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
  • [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology]
  • [http://partsregistry.org/Main_Page The registry]
  • [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
  • [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide]




Tour eiffel.gif

Project


Below, our wiki pages during work in summer 2007.


Life in the Lab

  • [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry]



The team at work

From October 17th 2007:
Locations of visitors to this page
Web Counters
Hit Counters


We are extremely grateful to the following organisations for their support of our project:

Paris Sponsors.jpg

Fondation Bettencourt

[http://www.fondationbs.org/ www.fondationbs.org]


Sofinnova

[http://www.sofinnova.fr www.sofinnova.fr]


Ambassade de France aux Etats Unis

[http://www.ambafrance-us.org/ www.ambafrance-us.org]


Synbiocomm

[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]

IGEMteam5.jpg
Retrieved from "http://2007.igem.org/wiki/index.php/Paris"