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-	<center>[[Image:Igem Paris Ban.jpg]]</center>	+	[[Image:ParisLogoIGEM.jpg|350px|center]]
-	page under construction	+	<font size=14><center>The SMB: Synthetic Multicellular Bacterium</center></font> <br>
-	for more information about us	+
-	http://biosynthetique.free.fr {fr}	+
-	<div align="center">	+
-	{| cellspacing="2px" cellpadding="5" border="2" style="padding: 0px; width: 780px; color: black; background-color: white;"	+
-	|-valign="top"	+
-	|width=189.25px style="padding: 10px; background-color: lightblue; border: 2px solid black;" |	+
-	<center><h3><font color=#646464>Members</font></h3></center>	+	<br>
		+	{{Paris_MainMenu}}
-	'''Instructors'''
-	[[Ariel Lindner]]<br>	+
-	[[Alfonso Jaramillo]]<br>	+	The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.
-	[[Franck Delaplace]]<br>	+
-	[[Francois Kepes]]<br>	+
-	[[Samuel Bottani]]<br>	+	{{paris_video_modeling2}}
-	[[Vincent Schachter]]<br>	+
		+	For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of  our wiki.
		+
		+	----
		+
		+	<center>'''[[Going through our wiki|Going through our wiki]]'''</center>
		+
		+
		+
		+	<div align="center" >
		+	{| cellspacing="2px" cellpadding="5" border="2" style="padding: 0px; width: 780px; color: black; background-color: #708090;"
		+	|-valign="top"
		+	|width=189.25px style="padding: 10px; background-color: #E0FFFF; border: 2px solid black;" |
		+
		+	<center><h3>Members</h3>
	'''Student Members'''		'''Student Members'''
-	[[Aurélien Rizk]]<br>	+	[[User:Aurelien.rizk|Aurélien Rizk]]<br>
-	[[David Bikard]]<br>	+	[[User:David.bikard|David Bikard]]<br>
-	[[David Guegan]]<br>	+	[[User:Davidoff|David Guegan]]<br>
-	[[David Puyraimond]]<br>	+	[[User:Davidpz|David Puyraimond]]<br>
-	[[Damien Robert]]<br>	+	[[User:Eismoustique|Eimad Shotar]]<br>
-	[[Eimad Shotar]]<br>	+	[[User:fanny.c|Fanny Caffin]]<br>
-	[[Fanny Caffin]]<br>	+	[[User:Vieira|Gilles Vieira]]<br>
-	[[Gilles Vieira]]<br>	+	[[User:Nicolas C.|Nicolas Chiaruttini]]<br>
-	[[Nicolas Chiaruttini]]<br>	+	[[User:Thomasclozel|Thomas Clozel]]<br>
-	[[Rayna Stamboliyska]]<br>	+	[[User:Landrain|Thomas Landrain]]<br>
-	[[Reem Betari]]<br>	+
-	[[Thomas Clozel]]<br>	+
-	[[Thomas Landrain]]<br>	+	'''Instructors'''
		+
		+	[[User:Ablindner|Ariel Lindner]]<br>
		+	[[User:Alfonso|Alfonso Jaramillo]]<br>
		+	[[User:Delapla|Franck Delaplace]]<br>
		+	[[User:Kepes|Francois Kepes]]<br>
		+	[[User:Vschachter|Vincent Schachter]]<br>
		+	[[User:Bottani|Samuel Bottani]]<br>
	'''Advisors'''		'''Advisors'''
-	[[Chafika Chettaoui]]<br>	+	[[User:Spicher|Antoine Spicher]]<br>
-	[[Antoine Spicher]]<br>	+	[[User:flefevre|Francois Le Fevre]]<br>
-	[[Francois Le Fevre]]<br>	+	[[User:PTortosa|Pablo Tortosa]]<br>
-	[[Pablo Tortosa]]<br>	+	[[User:maria|Maria Suarez]]<br>
-	[[Maria Suarez]]<br>	+	[[User:SMIDTAS|Serge Smidtas]]<br>
		+	</center>
		+	|width=189.25px style="padding:10px; background-color: white; border: 2px solid black;" |
-	|width=189.25px style="padding:10px; background-color: #ffffff; border: 2px solid black;" |	+	<center><h3>Information</h3></center>
		+	'''Site Map'''
		+	*[[Paris|Main Page]]
		+	*[[Paris/Introduction|Introduction]]
		+	*[[Paris/DesignProcess |Design Process]]
		+	*[[Paris/Modeling|Modeling]]
		+	*[[Paris/ConstructionProcess |Construction Process]]
		+	*[[Paris/Results|Results]]
		+	*[[Paris/Perspectives|Perspectives]]
		+	*[[Paris/Acknowledgments|Acknowledgments]]
-	<center><h3><font color=#646464>Ressources</font></h3></center>	+	<br><br>
		+	'''Links'''
		+	* [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
		+	* [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology]
		+	* [http://partsregistry.org/Main_Page The registry]
		+	* [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
		+	* [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide]
		+	<br><br><br>
		+	<center>[[Image:Tour eiffel.gif|60px]]</center>
		+	|width=189.25px style="padding: 10px; background-color: #FFA07A; border: 2px solid black;" |
		+	<center><h3>Project</h3></center>
-	|width=189.25px style="padding: 10px; background-color: #FF3333; border: 2px solid black;" |	+	* '''[[Paris/Project Description| Project Description]]'''
		+	<br>
-	<center><h3><font color=#646464>Project</font></h3></center>	+	''Below, our wiki pages during work in summer 2007.''
		+
		+	'''Life in the Lab'''
		+	* [[Paris/Constructs| Molecular biology constructs]]
		+
		+	* [[Paris/Notebook_Calendar| Team Notebook]]
		+
		+	* [[Paris/Oligos| Oligos]]
		+
		+	* [[Paris/PROTOCOLS| Protocols]]
		+
		+	* [[Paris/Freezer| Freezer]]
		+
		+	* [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry]
		+
		+
		+	* [[Paris/DISCUSSION| Forum]]
		+
		+
		+	[[Paris/The team at work|The team at work]]
	|}		|}
-	</div>'''Links'''	+
-	* [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki]	+	<html>
-	* [http://partsregistry.org/Main_Page The registry]	+	From October 17th 2007:<br>
		+	<a href="http://www3.clustrmaps.com/counter/maps.php?url=https://2007.igem.org/Paris" id="clustrMapsLink"><img src="http://www3.clustrmaps.com/counter/index2.php?url=https://2007.igem.org/Paris" style="border:0px;" alt="Locations of visitors to this page" title="Locations of visitors to this page" id="clustrMapsImg" onError="this.onError=null; this.src='http://www2.clustrmaps.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://www2.clustrmaps.com'" />
		+	</a>
		+	<br>
		+	<a href="http://www.easycounter.com/">
		+	<img src="http://www.easycounter.com/counter.php?dbikard"
		+	border="0" alt="Web Counters"></a>
		+	<br><a href="http://www.easycounter.com/FreeCounter3.html">Hit Counters</a>
		+	</html>
		+
		+
		+	We are extremely grateful to the following organisations for their support of our project:
		+
		+	<table><tr><td>
		+
		+	</td><td>
		+	[[Image:Paris_Sponsors.jpg]]
		+	</td><td>
		+	Fondation Bettencourt
		+
		+	[http://www.fondationbs.org/ www.fondationbs.org]
		+
		+
		+	Sofinnova
		+
		+	[http://www.sofinnova.fr www.sofinnova.fr]
		+
		+
		+	Ambassade de France aux Etats Unis
		+
		+	[http://www.ambafrance-us.org/ www.ambafrance-us.org]
		+
		+
		+	Synbiocomm
		+
		+	[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]
		+	</td></tr></table>
		+
		+	[[Image:IGEMteam5.jpg|920px|center]]

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Latest revision as of 03:10, 27 October 2007

The SMB: Synthetic Multicellular Bacterium

The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

<object style="width:640px;height:480px"> <param name="movie" value="http://biosynthetique.free.fr/videos/flv_player/flvplayer.swf?image=http://biosynthetique.free.fr/photo/01.jpg&amp;autostart=false&amp;file=http://biosynthetique.free.fr/videos/finalv4.flv" /> <param name="quality" value="high" /> </object>

For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of our wiki.

---

Going through our wiki