Paris
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- | + | [[Image:ParisLogoIGEM.jpg|350px|center]] | |
- | + | <font size=14><center>The SMB: Synthetic Multicellular Bacterium</center></font> <br> | |
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- | < | + | <br> |
+ | {{Paris_MainMenu}} | ||
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- | [[ | + | The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB. |
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- | + | {{paris_video_modeling2}} | |
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+ | For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of our wiki. | ||
+ | |||
+ | ---- | ||
+ | |||
+ | <center>'''[[Going through our wiki|Going through our wiki]]'''</center> | ||
+ | |||
+ | |||
+ | |||
+ | <div align="center" > | ||
+ | {| cellspacing="2px" cellpadding="5" border="2" style="padding: 0px; width: 780px; color: black; background-color: #708090;" | ||
+ | |-valign="top" | ||
+ | |width=189.25px style="padding: 10px; background-color: #E0FFFF; border: 2px solid black;" | | ||
+ | |||
+ | <center><h3>Members</h3> | ||
'''Student Members''' | '''Student Members''' | ||
- | [[Aurélien Rizk]]<br> | + | [[User:Aurelien.rizk|Aurélien Rizk]]<br> |
- | [[David Bikard]]<br> | + | [[User:David.bikard|David Bikard]]<br> |
- | [[David Guegan]]<br> | + | [[User:Davidoff|David Guegan]]<br> |
- | [[David Puyraimond]]<br> | + | [[User:Davidpz|David Puyraimond]]<br> |
- | [[ | + | [[User:Eismoustique|Eimad Shotar]]<br> |
- | + | [[User:fanny.c|Fanny Caffin]]<br> | |
- | [[Fanny Caffin]]<br> | + | [[User:Vieira|Gilles Vieira]]<br> |
- | [[Gilles Vieira]]<br> | + | [[User:Nicolas C.|Nicolas Chiaruttini]]<br> |
- | [[Nicolas Chiaruttini]]<br> | + | [[User:Thomasclozel|Thomas Clozel]]<br> |
- | [[ | + | [[User:Landrain|Thomas Landrain]]<br> |
- | [[ | + | |
- | [[ | + | |
- | [[ | + | '''Instructors''' |
+ | |||
+ | [[User:Ablindner|Ariel Lindner]]<br> | ||
+ | [[User:Alfonso|Alfonso Jaramillo]]<br> | ||
+ | [[User:Delapla|Franck Delaplace]]<br> | ||
+ | [[User:Kepes|Francois Kepes]]<br> | ||
+ | [[User:Vschachter|Vincent Schachter]]<br> | ||
+ | [[User:Bottani|Samuel Bottani]]<br> | ||
'''Advisors''' | '''Advisors''' | ||
- | [[ | + | [[User:Spicher|Antoine Spicher]]<br> |
- | + | [[User:flefevre|Francois Le Fevre]]<br> | |
- | [[Francois Le Fevre]]<br> | + | [[User:PTortosa|Pablo Tortosa]]<br> |
- | [[Pablo Tortosa]]<br> | + | [[User:maria|Maria Suarez]]<br> |
- | [[Maria Suarez]]<br> | + | [[User:SMIDTAS|Serge Smidtas]]<br> |
+ | </center> | ||
+ | |width=189.25px style="padding:10px; background-color: white; border: 2px solid black;" | | ||
- | | | + | <center><h3>Information</h3></center> |
+ | '''Site Map''' | ||
+ | *[[Paris|Main Page]] | ||
+ | *[[Paris/Introduction|Introduction]] | ||
+ | *[[Paris/DesignProcess |Design Process]] | ||
+ | *[[Paris/Modeling|Modeling]] | ||
+ | *[[Paris/ConstructionProcess |Construction Process]] | ||
+ | *[[Paris/Results|Results]] | ||
+ | *[[Paris/Perspectives|Perspectives]] | ||
+ | *[[Paris/Acknowledgments|Acknowledgments]] | ||
- | < | + | <br><br> |
+ | '''Links''' | ||
+ | * [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)] | ||
+ | * [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology] | ||
+ | * [http://partsregistry.org/Main_Page The registry] | ||
+ | * [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials] | ||
+ | * [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide] | ||
+ | <br><br><br> | ||
+ | <center>[[Image:Tour eiffel.gif|60px]]</center> | ||
+ | |width=189.25px style="padding: 10px; background-color: #FFA07A; border: 2px solid black;" | | ||
+ | <center><h3>Project</h3></center> | ||
- | | | + | * '''[[Paris/Project Description| Project Description]]''' |
+ | <br> | ||
- | + | ''Below, our wiki pages during work in summer 2007.'' | |
+ | |||
+ | '''Life in the Lab''' | ||
+ | * [[Paris/Constructs| Molecular biology constructs]] | ||
+ | |||
+ | * [[Paris/Notebook_Calendar| Team Notebook]] | ||
+ | |||
+ | * [[Paris/Oligos| Oligos]] | ||
+ | |||
+ | * [[Paris/PROTOCOLS| Protocols]] | ||
+ | |||
+ | * [[Paris/Freezer| Freezer]] | ||
+ | |||
+ | * [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry] | ||
+ | |||
+ | |||
+ | * [[Paris/DISCUSSION| Forum]] | ||
+ | |||
+ | |||
+ | [[Paris/The team at work|The team at work]] | ||
|} | |} | ||
- | </ | + | |
+ | <html> | ||
+ | From October 17th 2007:<br> | ||
+ | <a href="http://www3.clustrmaps.com/counter/maps.php?url=https://2007.igem.org/Paris" id="clustrMapsLink"><img src="http://www3.clustrmaps.com/counter/index2.php?url=https://2007.igem.org/Paris" style="border:0px;" alt="Locations of visitors to this page" title="Locations of visitors to this page" id="clustrMapsImg" onError="this.onError=null; this.src='http://www2.clustrmaps.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://www2.clustrmaps.com'" /> | ||
+ | </a> | ||
+ | <br> | ||
+ | <a href="http://www.easycounter.com/"> | ||
+ | <img src="http://www.easycounter.com/counter.php?dbikard" | ||
+ | border="0" alt="Web Counters"></a> | ||
+ | <br><a href="http://www.easycounter.com/FreeCounter3.html">Hit Counters</a> | ||
+ | </html> | ||
+ | |||
+ | |||
+ | We are extremely grateful to the following organisations for their support of our project: | ||
+ | |||
+ | <table><tr><td> | ||
+ | |||
+ | </td><td> | ||
+ | [[Image:Paris_Sponsors.jpg]] | ||
+ | </td><td> | ||
+ | Fondation Bettencourt | ||
+ | |||
+ | [http://www.fondationbs.org/ www.fondationbs.org] | ||
+ | |||
+ | |||
+ | Sofinnova | ||
+ | |||
+ | [http://www.sofinnova.fr www.sofinnova.fr] | ||
+ | |||
+ | |||
+ | Ambassade de France aux Etats Unis | ||
+ | |||
+ | [http://www.ambafrance-us.org/ www.ambafrance-us.org] | ||
+ | |||
+ | |||
+ | Synbiocomm | ||
+ | |||
+ | [http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch] | ||
+ | </td></tr></table> | ||
+ | |||
+ | [[Image:IGEMteam5.jpg|920px|center]] |
Latest revision as of 03:10, 27 October 2007
The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.
For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of our wiki.
MembersStudent Members Aurélien Rizk
Ariel Lindner Advisors Antoine Spicher |
InformationSite Map
![]() |
Project
Below, our wiki pages during work in summer 2007.
|
From October 17th 2007:
Hit Counters
We are extremely grateful to the following organisations for their support of our project:
Fondation Bettencourt [http://www.fondationbs.org/ www.fondationbs.org]
[http://www.sofinnova.fr www.sofinnova.fr]
[http://www.ambafrance-us.org/ www.ambafrance-us.org]
[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch] |