Paris

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<font size=16><center>The SMB: Synthetic Multicellular Bacterium</center></font> <br>
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<font size=18><center>The SMB: Synthetic Multicellular Bacterium</center></font> <br>
 
The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems.  It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.
The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems.  It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

Revision as of 08:58, 25 October 2007

ParisLogoIGEM.jpg
The SMB: Synthetic Multicellular Bacterium



The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.

Members

Student Members

Aurélien Rizk
David Bikard
David Guegan
David Puyraimond
Eimad Shotar
Gilles Vieira
Nicolas Chiaruttini
Thomas Clozel
Thomas Landrain


Instructors

Ariel Lindner
Alfonso Jaramillo
Franck Delaplace
Francois Kepes
Vincent Schachter
Samuel Bottani

Advisors

Chafika Chettaoui|
Antoine Spicher
Francois Le Fevre
Pablo Tortosa
Maria Suarez
Serge Smidtas

Informations



Summary of the teachers workshop

Schedule

  • Next meeting : Wednesday october 24th

Results, Conclusions, Wiki

Wiki freezing: D-5 !!

Links

  • [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
  • [http://partsregistry.org/Main_Page The registry]
  • [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
  • [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide]




Tour eiffel.gif

Project



Life in the Lab

  • [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry]



The team at work

From October 17th 2007:
Locations of visitors to this page
Web Counters
Hit Counters


We are extremely grateful to the following organisations for their support of our project:

Paris Sponsors.jpg

Fondation Bettencourt

[http://www.fondationbs.org/ www.fondationbs.org]


Sofinnova

[http://www.sofinnova.fr www.sofinnova.fr]


Ambassade de France aux Etats Unis

[http://www.ambafrance-us.org/ www.ambafrance-us.org]


Synbiocomm

[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]