Paris

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The SMB: Synthetic Multicellular Bacterium



The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a novel tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first, dedicated to reproduction is the germ line (red cells in the simulation below). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, requires the germ line for its generation, while the germ line needs the soma to complement its auxotrophy. We provide here both experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.


modeling <object style="width:640px;height:480px"> <param name="movie" value="http://biosynthetique.free.fr/videos/flv_player/flvplayer.swf?image=http://biosynthetique.free.fr/photo/01.jpg&amp;autostart=false&amp;file=http://biosynthetique.free.fr/videos/finalv4.flv" /> <param name="quality" value="high" /> </object>

For your convenience, [http://biosynthetique.free.fr/pdf/Paris_igem07.pdf download] a printable pdf version of our wiki.


Going through our wiki


Members

Student Members

Aurélien Rizk
David Bikard
David Guegan
David Puyraimond
Eimad Shotar
Fanny Caffin
Gilles Vieira
Nicolas Chiaruttini
Thomas Clozel
Thomas Landrain


Instructors

Ariel Lindner
Alfonso Jaramillo
Franck Delaplace
Francois Kepes
Vincent Schachter
Samuel Bottani

Advisors

Antoine Spicher
Francois Le Fevre
Pablo Tortosa
Maria Suarez
Serge Smidtas

Information

Site Map




Links

  • [http://biosynthetique.free.fr/index.php5?title=Accueil Our French wiki (SB 2006/06 journal club)]
  • [http://www.biologiesynthetique.fr A wiki (in french) on synthetic biology]
  • [http://partsregistry.org/Main_Page The registry]
  • [http://partsregistry.org/Help:Contents Biobricks and Registry Tutorials]
  • [http://en.wikipedia.org/wiki/Help:Wikitext_examples Wiki Formatting Guide]




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Project


Below, our wiki pages during work in summer 2007.


Life in the Lab

  • [http://partsregistry.org/cgi/partsdb/pgroup.cgi?pgroup=iGEM2007&group=Paris Our parts at the registry]



The team at work

From October 17th 2007:
Locations of visitors to this page
Web Counters
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We are extremely grateful to the following organisations for their support of our project:

Paris Sponsors.jpg

Fondation Bettencourt

[http://www.fondationbs.org/ www.fondationbs.org]


Sofinnova

[http://www.sofinnova.fr www.sofinnova.fr]


Ambassade de France aux Etats Unis

[http://www.ambafrance-us.org/ www.ambafrance-us.org]


Synbiocomm

[http://www.syntheticbiology.ethz.ch/synbiocomm/index www.syntheticbiology.ethz.ch]

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