Tokyo/Requirements
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====1. Bistability==== | ====1. Bistability==== | ||
<!--これがないと、動的平衡になってしまう。<br>Without this, our model is subject to dynamic equilibrium.--> | <!--これがないと、動的平衡になってしまう。<br>Without this, our model is subject to dynamic equilibrium.--> | ||
| - | ''' | + | '''Stability at an individual level''' |
For "stable coexistence" in our model, two types of cells should coexist stably. Therefore, cells with '''THE SAME GENE SET''' need to take either of '''TWO STATES''', A (Worker) or B (Idler) in our project as shown in Fig. 1. '''In order to distinguish from dynamic stability, "stable coexistence" must be achieved by two distinct states inconvertible each other.''' | For "stable coexistence" in our model, two types of cells should coexist stably. Therefore, cells with '''THE SAME GENE SET''' need to take either of '''TWO STATES''', A (Worker) or B (Idler) in our project as shown in Fig. 1. '''In order to distinguish from dynamic stability, "stable coexistence" must be achieved by two distinct states inconvertible each other.''' | ||
Revision as of 11:56, 24 October 2007
Abstract Concept & Model Requirements Genetic_circuit Works About_our_team
The most important and underlying point of our model is that the system is stable against environmental changes when two or more types of individuals coexist, called "stable coexistence." Our project have aimed at this "stable coexistence" but not dynamic equilibrium such as chemical ones.
To achieve this “stable coexistence", our model requires
1. bistability at two distinct states in a single cell
2. cell-cell communication by quarum sensing
1. Bistability
Stability at an individual level
For "stable coexistence" in our model, two types of cells should coexist stably. Therefore, cells with THE SAME GENE SET need to take either of TWO STATES, A (Worker) or B (Idler) in our project as shown in Fig. 1. In order to distinguish from dynamic stability, "stable coexistence" must be achieved by two distinct states inconvertible each other.
2. Cell-cell communication
When this stable coexistence is disrupted, by removing all the A type for example, these individual cells sense the change. Their states A or B become unstable as if cells became upset - INDIVIDUAL STATES ARE UNSTABLE ⇒ They are COLLECTIVELY UNSTABLE. Then some of them changed their states while the others do not. As a result, at a certain ratio of A and B again, the whole system comes back to a stable states. Here the cells are COLLECTIVELY STABLE ⇒ INDIVIDUALS ARE STABLE under this stable coexistence.
