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The SMB: Synthetic Multicellular Bacterium

The aim of our project is to engineer the first synthetic multicellular bacterium, the SMB. This new organism is a new tool for the engineering of complex biological systems. It consists in two interdependent cell lines. The first one, dedicated to reproduction will be called the germ line (red cells). It is able to differentiate into the second line: the soma (green cells), which is sterile and dedicated to support the germ line. The germ line is auxotroph for DAP (diaminopimelate) which is provided by the soma. There is thus an interdependency relationship. The soma, being sterile, doesn't exist without the germ line to generate it, and the germ line needs the soma to complement its auxotrophy. We provide here experimental and computational evidences that this system can work, as well as the almost complete construction of the SMB.


Student Members

Aurélien Rizk
David Bikard
David Guegan
David Puyraimond
Eimad Shotar
Gilles Vieira
Nicolas Chiaruttini
Thomas Clozel
Thomas Landrain


Ariel Lindner
Alfonso Jaramillo
Franck Delaplace
Francois Kepes
Vincent Schachter
Samuel Bottani


Chafika Chettaoui|
Antoine Spicher
Francois Le Fevre
Pablo Tortosa
Maria Suarez
Serge Smidtas


Summary of the teachers workshop


  • Next meeting : Wednesday october 24th

Results, Conclusions, Wiki

Wiki freezing: D-5 !!


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Life in the Lab

The team at work

From October 17th 2007:
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We are extremely grateful to the following organisations for their support of our project:

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Fondation Bettencourt


Ambassade de France aux Etats Unis