USTC

Our Project:
Extensible Logic Circuit in Bacteria

Logic Artificial Biological Circuit (ABC) and logic Integrated Circuit (IC) are both composed by "components" and "wires". Though we have been enjoying the advantages of Ultra Large Scale IC (ULSI), we still cannot implement in real experiments a somewhat large-scaled logic ABC with several levels of logic gates in it.

Our project is to provide a new method for building up a fully extensible logic ABC. For some biological convenience, we are going to produce such biological logic gates as NAND, NOR, NOT which are exactly the basis for modern logic IC. Anyway, logic gates are just the basic components of logic IC. There are factors considered more important to let IC to be easily enlarged. For example, size reduction, the power and response time of the components, modulation of the components to eliminate interference, calibration of them for their interaction. Cis-acting components in ABC may present a smaller scale than trans-acting ones, while the other two factors can be achieved by novelly-designed and calibrated wires. We are also going to demonstrate an ABC made by these biological logic gates and wires.

Such an ABC may not be large, but the important factors we implement in it will naturally make it fully extensible. IC has existed for 50 years, and now how huge its impact is on our modern lives! Then what about the biological logic circuits in the next 50 years? A new world is waiting...

From left to right
Back row: Zhao Yun, Liu ZQ, Ma XY
Front row: Ma Rui, Su XF, Ding Bo, Zhan Jian

Events

11/08/2007
Double reporter system:

The E.Coli cultured from the blue colony shows only very weak green fluorensce intensity. We are considering applying some high copy-number plasmid where the double genes are held.

01/08/2007
There is a mistake in my preparing X-Gal solution. Please rework your correlative experiments. Sorry! (by Ma Rui)

30/07/2007
First designed repressors. Good work, Bo and Xiaofeng!

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