Tokyo/Formulation/5.stochastic differential equation model with poisson random variables

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Works top　　0.Hybrid promoter　　1.Formulation　　2.Assay1　　3.Simulation　　4.Assay2　　5.Future works

Step1　　Step2　　Step3　　Step4　　Step5

we introduced the terms of Ex 4-1 into a stochastic process to simulate the sthochastic behavior.we used Poisson random variables as a sthochastic process. Threfore,a stochastic differential equations were given as


Ex 5-1
Table 5


ここより下は独立したページにすべき？



The values of parameters in the right table were used and the results of simulation were shown in Fig 5.1-3.



where α2 = 1(μM) in Fig 5.1,α2 = 2.7(μM) in Fig 5.2,α2 = 4(μM) in Fig 5.3. and it has been estimated that 1(μM) = 1000 molecules (count).


Fig.5.1 indicates that all cells shift to A state in the steady state and Fig 5.3 indicates that all cells shift to B state in the steady state.These results doesn't represent coexistence stable.
Fig.5.2 indicates that a portion of cells shift to A state and the others shift to B state in steady state;that is,individual cells are stable under stable coexistence.

Figure 5.1.A 　t=0.2(min)
Arrow2.JPG
Figure 5.1.B 　t=0.8(min)
Arrow2.JPG
Figure 5.1.C 　 t=30(min)　only A

movie here!!


Figure 5.2.A 　t=0.2(min)
Arrow2.JPG
Figure 5.2.B 　 t=0.8(min)
Arrow2.JPG
Figure 5.2.C 　 t=30(min)　　success!! coexistence

movie here!!


Figure 5.3.A 　 t=0.2(min)
Arrow2.JPG
Figure 5.3.B 　 t=0.8(min)
Arrow2.JPG
Figure 5.3.C 　 t=30(min)　　 only B

movie here!!


Next，the relation between the results of simulation and phase plane are shown in Fig.5.4.1-3,where the nullclines of this system were Ex 4-3

Figure 5.4.1
Figure 5.4.2
Figure 5.4.3


Fig.5.4.1-3 indicate that the distribution of the cells corresponds with the stable equilibrium points.

Step.5 >> Formulation TOP

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